THE DOUBLE HELIX

The classic personal account of Watson and Crick’s groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind.

By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.

Preface

HERE I relate my version of how the structure of DNA was discovered. In doing so I have tried to catch the atmosphere of the early postwar years in England, where most of the important eventsoccurred. As I hope this book will show, science seldom proceeds in the straightforward logical manner imagined by outsiders. Instead, its steps forward (and sometimes backward) are often very human events in which personalities and cultura1 traditions play major roles. To this end I have attempted to recreate my first impressions of the relevant events and personalities rather than present an assessment which takes into account the many facts I have learned since the structure was found. Although the latter approach might be more objective, it would fail to convey the spirit of an adventure characterized both by youthful arrogance and by the belief that the truth, once found, would be simple as well as pretty. Thus many of the comments may seem one-sided and unfair, but this is often the case in the incomplete and hurried way in which human beings frequently decide to like or dislike a new idea or acquaintance. In any event, this account represents the way I saw things then, in 1951-1953: the ideas, the people, and myself.

I am aware that the other participants in this story would tell parts of it in other ways,sometimes because their memory of what happened differs from mine and, perhaps in even more cases, because no two people ever see the same events in exactly the same light. In this sense, no one will ever be able to write a definitive history of how the structure was established. Nonetheless,I feel the story should be told, partly because many of my scientific friends have expressed curiosity about how the double helix was found, and to them an incomplete version is better than none. But even more important, I believe, there remains general ignorance about how science is

"done." That is not to say that all science is done in the manner described here. This is far from the case, for styles of scientific research vary almost as much as human personalities. on the other hand, I do not believe that the way DNA came out constitutes an odd exception to a scientific world complicated by the contradictory pulls of ambition and the sense of fair play. The thought that I should write this book has been with me almost from the moment the double helix was found. Thus my memory of many of the significant events is much more complete than that of most other

episodes in my life. I also have made extensive use of letters Written at virtually weekly intervals to my parents. These were especially helpful in exactly dating a number of the incidents. Equally important have been the valuable comments by various friends who kindly read earlier versions and gave in some instances quite detailed accounts of incidents that I had referred to in less complete form. To be sure, there are cases where my recollections differ from theirs, and so this book must be regarded as my view of the matter.

Some of the earlier chapters were written in the homes of Albert Szent-Györgyi, John A. Wheeler, and John Cairns, and I wish to thank them for quiet rooms with tables overlooking the ocean. The later chapters were written with the help of a Guggenheim Fellowship, which allowed me hospitality of the Provost and Fellows of King’s College.

As far as possible I have included photographs taken at the time the story occurred, and in particular I want to thank Herbert Gutfreund, Peter Pauling, Hugh Huxley, and Gunther Stent for sending me some of their snapshots. For editorial assistance I'm much indebted to Libby Aldrich for the quick, perceptive remarks expected from our best Radcliffe students and to Joyce Lebowitz both for keeping me from completely misusing the English language and for Innumerable comments about what a good book must do. Finally, I wish to express thanks for the immense help Thomas J. Wilson has given me from the time he saw the first draft. Without his wise, warm, and

sensible advice, the appearance of this book, in what I hope is the right form, might never have occurred.

J. D.W.

Harvard University

Cambridge, Massachusetts
November 1967